Closer to Fine

Closer to fine: fewer steps to endothelial stemness.

Yamanaka’s pioneering work demonstrating the ability of fully differentiated cells to reprogram into embryonic stem cells with just four factors (c-Myc, Oct3/4, Sox2, and Klf4) ushered in a new era of regenerative biology.1 Although it is currently thought that reprogramming of differentiated cells to a pluripotent state involves multiple stochastic epigenetic events, progenitors with some degr...

Closer to Quantum Internet

Quantum computers are one of the most promising technologies under development, and all their promises are completely justified. Quantum systems are extremely expensive to compute, where “expensiveness” can be measured either by the memory or the computational time required in classical computers. But it should be much cheaper if the computer uses quantum mechanics rules. The comparison is simp...

Moving closer to the movement

Getting closer to p-selectin.

Inflammation is recognized for its important role in the pathophysiology of atherosclerosis (1 ). However, the use of genetic association studies to dissect the impact of inflammatory genes on vascular disease is challenging because of the relatively small effects expected for common variants and the difficulty of identifying surrogates that best reflect underlying disease processes. In this is...

A TAD closer to ATM

Ataxia telangiectasia mutated (ATM) has been known for decades as the main kinase mediating the DNA double-strand break response. Our recent findings suggest that its major role at the sites of breaks likely resides in its ability to modify both the local chromatin landscape and the global chromosome organization in order to promote repair accuracy.